MIDUS Genomics Repository

MIDUS has a variety of genetic data for the Core, Refresher, and MIDJA samples. This page explains which data are publicly available via the Portal and which are restricted access via the MIDUS Genetic Repository. Policy and guidelines for requesting access can be found here (Guidelines and Policy PDF). Below are details about available data and links to the Access Request and Data Sharing Agreement forms.

RNA Expression Values Data
CTRA (Conserved Transcriptional Response to Adversity) Data
CTRA data have been generated for individuals who completed the MIDUS Refresher Biomarker project. These data can be found in two files:

• Publicly Available - CTRA score data is publicly available through the MIDUS Colectica Portal.


• Restricted - CTRA gene expression values for 51 individual CTRA indicator genes along with relevant sample quality metrics and RNA covariates.
• Restricted CTRA data are currently available upon approval

DNA Derived Data
PRS (Polygenic Risk Score) and Imputed SNP (Single Nucleotide Polymorphism) Data

• Publicly Available - Polygenic Risk Score data is publicly available through the MIDUS Colectica Portal.
• PRS are available for some phenotypes that are commonly studied by users of the MIDUS data. A list of those PRS and related publications can be found here.


• Restricted -  Imputed SNP data have been generated for individuals who completed the MIDUS 2 and MIDUS Refresher 1 Biomarker data collection projects as well as the MIDJA 2 Biomarker data collection project.
• Restricted Imputed SNP data are currently available upon approval.

Methylation Age Scores Data

• Publicly Available - Methylation Age Scores data is publicly available through the MIDUS Colectica Portal.

Requesting Access
Researchers interested in requesting access to the genomics data must first complete an Access Request form here (fillable PDF) and submit it along with a copy of their current CV to midus_genomics@aging.wisc.edu.
Details about the information to be provided in this form can be found here (Guidelines and Policy PDF).  An example of a completed application can also be found here (application example).
Upon approval of the access request, users will need to complete a Data Sharing Agreement (DSA) form which will be emailed to them. 
Specific instructions and login information to access the genomics dataset(s) will be sent upon receipt of the completed DSA.